Category Archives: Science

Drugs and the Brain

Notes adapted from the Coursera course titled "Drugs and the Brain" taught by Dr. Lester from Caltech. 1-4: Drug Entry into the Nervous System Nicotine passes through 3 cell types and 6 cell membranes in under a few seconds. After being puffed in, it passes through alveolar epithelium cells, then it passes through two types… Read More »

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EZH2-mediated H3K27 trimetylation mediates neurodegeneration in ataxia-telangiectasia

Ataxia-telangiectasia (A-T) is a neurodegenerative disease caused by a mutation of the A-T mutated (ATM) gene ATM encodes a serine/threonine protein kinase of the phosphatidylinositol-3 kinase-related kinase (PIKK) family. ATM is responsible for activating cell cycle checkpoints that arrest the cell cycle until DNA repair is complete. Individuals with A-T are thus more likely to… Read More »

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Concepts in Medical Neuroscience

Many of these notes are adapted from Dr. White's Coursera course titled "Medical Neuroscience." 1-2: Functional Microanatomy of Neurons Neurons contain all the metabolic machinery common to other somatic cells (e.g., nuclei, mitochondria) Most neurons are incredibly rich in endoplasmic riticulum for synthesis of lipid (smooth ER) and protein molecules (rough ER) and mitochondria for… Read More »

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Common laboratory techniques

rt-PCR Real-time polymerase chain reaction (also known as quantitative polymerase chain reaction) is used to both amplify DNA (through PCR) and to quantify that amplification. The quantification is done via double stranded binding dyes. The fluorescence intensity of the dye is measured and results in quantifying the amount of DNA. This may be prone to… Read More »

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