Tag Archives: kinase

EZH2-mediated H3K27 trimetylation mediates neurodegeneration in ataxia-telangiectasia

Ataxia-telangiectasia (A-T) is a neurodegenerative disease caused by a mutation of the A-T mutated (ATM) gene ATM encodes a serine/threonine protein kinase of the phosphatidylinositol-3 kinase-related kinase (PIKK) family. ATM is responsible for activating cell cycle checkpoints that arrest the cell cycle until DNA repair is complete. Individuals with A-T are thus more likely to… Read More »